Diazepam is N-demethylated by CYP3A4 and 2C19 towards the active metabolite N-desmethyldiazepam, and is also hydroxylated by CYP3A4 towards the active metabolite temazepam. N-desmethyldiazepam and temazepam are equally additional metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation.In acute Liquor withdrawal, dia